Mae and Jack, accomplices in the distribution of marihuana, entice local high school kids to stop by Mae's apartment to smoke reefer, where stoned ne'er-do-wells laugh fiendishly, dance, and play the piano. Jack invites the clean-cut couple Bill and Mary up to his den of sin. After one joint, Bill is hooked, and his life begins to plummet down the tubes. When Mary smokes, she begins giggling uncontrollably while being aggressively fondled by the bizarre addict Ralph. Bill bursts out of the bedroom to tangle with Ralph, prompting a string of calamitous occurrences, including several more deaths and courtroom sentences to mental institutions, all because of the devil weed.


Bonus features include The Weed of Death! (1924); Cab Calloway in That Funny Reefer Man (1936); Betty Boop's Happy You and Merry Me (1936); High on the Range (1924); Marihuana: Sins of Youth (1936); Marihuana: Threat or Menace (1939); Hemp for Victory (1942); The Pusher (1951); the Reefer Madness Trailer remix and more.