In Scream 4, Sidney Prescott, now the author of a self-help book, returns home to Woodsboro on the last stop of her book tour. There she reconnects with Sheriff Dewey and Gale, who are now married, as well as her cousin Jill (played by Emma Roberts) and her Aunt Kate (Mary McDonnell). Unfortunately Sidney's appearance also brings about the return of Ghost Face, putting Sidney, Gale, and Dewey, along with Jill, her friends, and the whole town of Woodsboro in danger.

The newest installment in the acclaimed franchise that ushered in a new wave of horror in the 1990s is written by series creator Kevin Williamson and directed by suspense master and director of the first trilogy, Wes Craven. The film stars Neve Campbell, Courteney Cox, David Arquette, Emma Roberts, Hayden Panettiere, Rory Culkin, Anthony Anderson, Adam Brody, Mary McDonnell, Marley Shelton, Nico Tortorella, Marielle Jaffe, Kristen Bell, Anna Paquin, Lucy Hale, Shanae Grimes, Aimee Teegarden and Brittany Robertson.