Derek Zoolander (Ben Stiller) isn't smart, but he looks "really, really good." An empty-headed yet kindhearted male model, the self-absorbed Derek becomes an unwitting pawn in a international assassination plot masterminded by oddball fashion dictator Jacobim Mugatu (Will Ferrell). Meanwhile, the clueless cover guy must also contend with a new rival, a blonde hipster named Hansel (Owen Wilson). Only adding to his troubles is Matilda Jeffries (Christine Taylor), an inquisitive and sensitive journalist.

Stiller's charming and silly comedy liberally skewers the fashion industry while showcasing the actor-director-screenwriter's quirky humor. He casts his real-life family in the film: wife Christine Taylor, sister Amy Stiller, father Jerry Stiller, and mother Anne Meara. As a director, Stiller invokes entertaining performances from Wilson and Ferrell. He also adds cameos by a multitude of celebrities including David Bowie, Natalie Portman, and Lenny Kravitz.