Lily Tomlin stars as Pat Kramer, an ordinary housewife living in a quiet suburban environment. Her over-achieving, advertising executive husband treats her to all the goodies that his company represents. But it seems that Pat has developed an odd reaction to the chemicals in all those soaps, hairsprays and dishwashing detergents that hubby has been bringing home. And little by little, Pat begins to shrink -- to the point where at two feet tall she is a celebrity appearing on talk shows. But an evil syndicate known only as "World Management" decides to kidnap Pat, and use her blood to make a serum and shrink the entire world population. Now Pat and her family have to figure out how to return her to normal size and save the world in the process.