Matthew McConaughey headlines director Jean-Marc Vallée's biographical drama centering on the story of Ron Woodroof, a Texas electrician who was diagnosed as HIV-positive in 1986, and who subsequently devoted his life to providing fellow HIV patients with non-FDA-approved drugs and supplements during an era when doctors were still struggling to understand the devastating disease. Defying his surprise death sentence, Woodroof set out to procure any and all non-toxic alternative HIV treatments available, and established a "buyers club" to provide the treatments to others afflicted with the disease. But that mission quickly made him a target for both the U.S. medical establishment and the pharmaceutical industry, both of which resented his defiance of government sanctions, and joined forces to shut down his operation by any means necessary.