The year is 2078. The man is rebel Alliance Commander Col. Joseph Hendricksson (Peter Weller), assigned to protect the Sirius 6B outpost from ravage and plunder at the hands of the New Economic Bloc. His state-of-the-art weaponry is known as Screamers: man-made killing devices programmed to eliminate all enemy life forms. Screamers travel underground, their intent to kill announced by ear-piercing shrieks. They dissect their victims with precision, then eradicate all traces of the carnage. They are lethal. Effective. Tidy. And, somehow, they are mutating and self-replicating into human form and slaughtering every beating heart on the planet.