Jenna, who has fallen victim to a strange vampiric/zombie plague, sets out with her father to find and destroy the source of the vile infection. Only then will she be saved. Along the way, they agree to provide safe passage for a mysterious woman, unaware she is actually Carmilla - a centuries-old baroness and the source of the plague! To make matters worse, the countryside is infected with armies of ferocious zombies. In order to survive, they ally with The General, who has his own score to settle with Carmilla, as well as the weapons and the means to do it. As the men battle endless attacks from the living dead, Carmilla slowly seduces Jenna in mind and body.

Based on the novel CARMILLA by Sheridan Le Fanu, VAMPIRES VS. ZOMBIES pits two of horrordom's most feared creatures against one another. When young Jenna becomes affected by a mysterious vampiric disease, she begins to hallucinate, and her father whisks her away on a journey to find the source of the infection. On their way to the hometown of Baroness Vampire Carmilla, suspected to be the cause of the problem, the two encounter a friendly General, school-girl zombies, cannibals, and of course, the power-mad, evil Carmilla!